Hereditary pancreatitis
From Wikipedia, the free encyclopedia
Hereditary Pancreatitis is a genetic disease affecting enzyme production in the pancreas. In the pancreas, a genetic mutation causes the enzyme trypsinogen to be made in a way which renders it resistant to inactivation through autolysis. Normally this autolysis mechanism prevents trypsinogen from being activated within the pancreas. However, when the abnormal trypsinogen is activated, it causes a chain reaction where all the trypsinogen in the pancreas is activated, effectively digesting the pancreas from the inside.
Symptoms and Treatment
Symptoms are generally the same as acute pancreatitis, including severe abdominal pain, vomiting, and diarrhea. There is no treatment for the disease, although complications such as malnutrition can be treated with supplimentary pancreatic enzymes.
Most estimates place the number of individuals with hereditary pancreatitis in the United States at 1000.
References
http://gut.bmjjournals.com/cgi/content/full/45/3/317
| Health science - Medicine - Gastroenterology - edit |
|---|
| Diseases of the esophagus - stomach |
| Halitosis | Nausea | Vomiting | GERD | Achalasia | Esophageal cancer | Esophageal varices | Peptic ulcer | Abdominal pain | Stomach cancer | Non-ulcer dyspepsia | Gastroparesis | Abdominal angina | Malabsorption (e.g. celiac disease, giardiasis) |
| Diseases of the liver - pancreas - gallbladder - biliary tree |
| Hepatitis | Cirrhosis | NASH | PBC | PSC | Budd-Chiari | Hepatocellular carcinoma | Acute pancreatitis | Chronic pancreatitis | Hereditary pancreatitis | Pancreatic cancer | Gallstones | Cholecystitis | Malabsorption (eg. cystic fibrosis) |
| Diseases of the small intestine |
| Peptic ulcer | Intussusception | Malabsorption (e.g. Coeliac, lactose intolerance, fructose malabsorption, Whipple's) | Lymphoma |
| Diseases of the colon |
| Diarrhea | Appendicitis | Diverticulitis | Diverticulosis | IBD (Crohn's, Ulcerative colitis) | IBS | Constipation | Colorectal cancer | Hirschsprung's | Pseudomembranous colitis |
Categories: Medical emergencies | Gastroenterology

