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Eclampsia is a serious complication of pregnancy and is characterised by convulsions. Usually eclampsia occurs after the onset of pre-eclampsia though sometimes no pre-eclamptic symptoms are recognisable. The convulsions may appear before, during or after labour, though cases of eclampsia after just 20 weeks of pregnancy have been recorded.
Signs and symptoms
The majority of cases are heralded by pregnancy-induced hypertension and proteinuria but the only true sign of eclampsia is an eclamptic convulsion, of which there are four stages. Patients with edema and oliguria may develop renal failure or pulmonary edema.
- Premonitory stage
- this stage is usually missed unless constantly monitored, the woman rolls her eyes while her facial and hand muscles twitch slightly.
- Tonic stage
- soon after the premonitory stage the twitching turns into clenching. Sometimes the woman may bite her tongue as she clenches her teeth, while the arms and legs go rigid. The respiratory muscles also spasm, causing the woman to stop breathing. This stage continues for around 30 seconds.
- Clonic stage
- the spasm stops but the muscles start to jerk violently. Frothy, slightly bloodied saliva appears on the lips and can sometimes be inhaled. After around two minutes the convulsions stop, leading into a coma, but some cases lead to heart failure.
- Comatose stage
- the woman falls deeply unconscious, breathing noisily. This can last only a few minutes or may persist for hours.
Eclampsia can be fatal to both mother and fetus, with just under one in 50 affected women and one in 14 fetuses of affected women dying despite best-available medical care.
The treatment of seizures in eclampsia consists of: - Prevention of convulsion - Control the blood pressure - Termination of pregnancy
Prevention of convulsion is usually done using magnesium sulfate with a loading of Manesium sulfate 20% solution, 4 g IV over 5 minutes. Then maintain with 1 g magnesium sulfate (10%solution) in 1000 ml fluid drip 1g/hr.
The blood pressure may be controlled by hydralazine 5 mg IV slowly every 5 minutes until blood pressure is lowered. Repeat hourly as needed or give hydralazine 12.5 mg IM every 2 hours as needed.
Delivery should take place as soon as the woman’s condition has stabilized. Delaying delivery to increase fetal maturity will risk the lives of both the woman and the fetus. Delivery should occur regardless of the gestational age.
In severe pre-eclampsia, delivery should occur within 24 hours of the onset of symptoms. In eclampsia, delivery should occur within 12 hours of the onset of convulsions. If vaginal delivery is not anticipated within 12 hours (for eclampsia) or 24 hours (for severe pre-eclampsia), deliver by caesarean section.
- Mayes, M., Sweet, B. R. & Tiran, D. (1997). Mayes' Midwifery - A Textbook for Midwives 12th Edition, pp. 533–545. Baillière Tindall. ISBN 0-7020-1757-4